Posts Tagged ‘ observational ’

Clinical trials: enrollment targets vs. valid hypothesis testing

August 20, 2012
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Clinical trials: enrollment targets vs. valid hypothesis testing

The questions raised in this Scientific American article ought to concern all of us, and I want to take some of these questions further. But let me first explain the problem. Clinical trials and observational studies of drugs, biologics, and medical de...

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Observational data is valuable

August 13, 2012
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Observational data is valuable

I’ve heard way too many times that observational studies are flawed, and to really confirm a hypothesis you have to do randomized controlled trials. Indeed, this was an argument in the hormone replacement therapy (HRT) controversy (scroll down for th...

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